H2N2V1, Main, Exploration, bibRecord, 000D79

Treatment options for 2009 H1N1 influenza: evaluation of the published evidence

Identifieur interne : 000D79 ( Main/Exploration ); précédent : 000D78; suivant : 000D80

Treatment options for 2009 H1N1 influenza: evaluation of the published evidence

Auteurs : Matthew E. Falagas [Grèce] ; Evridiki K. Vouloumanou [Grèce] ; Evagelia Baskouta [Grèce] ; Petros I. Rafailidis [Grèce] ; Kostantinos Polyzos [Grèce] ; Jordi Rello [Espagne]

Source :

International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2010-03-19.

RBID : Hal:hal-00578292

Abstract

We evaluated the evidence regarding the effectiveness of various treatment strategies used for 2009 H1N1 influenza by reviewing available relevant studies. In total, 22 studies (15 cohort studies involving >10 patients, 5 cohort studies with ≤10 patients and 2 case reports) were included. A total of 3020 patients [1068 (35.4%) critically ill, 1722 (57.0%) hospitalised and 230 (7.6%) outpatients, including 909 (30.1%) children] were involved. Notably, 487 (16.1%) were obese [body mass index (BMI) >30)], 362 (12.0%) had asthma or chronic obstructive pulmonary disease and 255 (8.4%) were pregnant. Antiviral treatment was administered to 1622 patients (53.7%), of whom 661 (40.8%) received oseltamivir monotherapy. Corticosteroids were administered in 323 (31.8%) of 1016 patients for whom relevant data were available. Similarly, 633 (85.0%) of 745 patients received antibiotics. Comparative data from the largest included study (involving 1088 patients) indicated that administration of antivirals within 2 days from symptom onset was significantly associated with reduced mortality (<0.001). In summary, the scarcity of comparative available data hampered the establishment of any firm conclusions regarding the benefit that various treatment strategies may confer to patients with 2009 H1N1 influenza. Studies with a comparative design as well as randomised studies are needed to clarify further this issue of major importance.

Url:

https://hal.archives-ouvertes.fr/hal-00578292

DOI: 10.1016/j.ijantimicag.2010.01.006

Affiliations:

Espagne, Grèce

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Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>We evaluated the evidence regarding the effectiveness of various treatment strategies used for 2009 H1N1 influenza by reviewing available relevant studies. In total, 22 studies (15 cohort studies involving >10 patients, 5 cohort studies with ≤10 patients and 2 case reports) were included. A total of 3020 patients [1068 (35.4%) critically ill, 1722 (57.0%) hospitalised and 230 (7.6%) outpatients, including 909 (30.1%) children] were involved. Notably, 487 (16.1%) were obese [body mass index (BMI) >30)], 362 (12.0%) had asthma or chronic obstructive pulmonary disease and 255 (8.4%) were pregnant. Antiviral treatment was administered to 1622 patients (53.7%), of whom 661 (40.8%) received oseltamivir monotherapy. Corticosteroids were administered in 323 (31.8%) of 1016 patients for whom relevant data were available. Similarly, 633 (85.0%) of 745 patients received antibiotics. Comparative data from the largest included study (involving 1088 patients) indicated that administration of antivirals within 2 days from symptom onset was significantly associated with reduced mortality (<0.001). In summary, the scarcity of comparative available data hampered the establishment of any firm conclusions regarding the benefit that various treatment strategies may confer to patients with 2009 H1N1 influenza. Studies with a comparative design as well as randomised studies are needed to clarify further this issue of major importance.</p>
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Treatment options for 2009 H1N1 influenza: evaluation of the published evidence

Treatment options for 2009 H1N1 influenza: evaluation of the published evidence

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Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri